CORO1C

CORO1C
Identifiers
Aliases	CORO1C, HCRNN4, coronin 1C
External IDs	OMIM: 605269; MGI: 1345964; HomoloGene: 56537; GeneCards: CORO1C; OMA:CORO1C - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	108,731,526 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	114,046,819 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; tendon of biceps brachii; ; ganglionic eminence; ; synovial joint; ; Achilles tendon; ; stromal cell of endometrium; ; epithelium of colon; ; urethra; ; popliteal artery; ; tibial arteries;
	Top expressed in
	stroma of bone marrow; ; corneal stroma; ; ventricular zone; ; yolk sac; ; somite; ; ileum; ; epiblast; ; intestinal villus; ; ganglionic eminence; ; crypt of lieberkuhn of small intestine;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin filament binding; protein binding; actin binding;
Cellular component	cytoplasm; vesicle; cell projection; lateral plasma membrane; membrane; focal adhesion; plasma membrane; flotillin complex; actin cytoskeleton; cytoskeleton; lamellipodium;
Biological process	regulation of protein phosphorylation; negative regulation of protein phosphorylation; positive regulation of lamellipodium morphogenesis; activation of GTPase activity; establishment of protein localization; regulation of epithelial cell migration; neural crest cell migration; negative regulation of protein kinase activity by regulation of protein phosphorylation; phagocytosis; regulation of focal adhesion assembly; regulation of ruffle assembly; negative regulation of substrate adhesion-dependent cell spreading; regulation of fibroblast migration; regulation of substrate adhesion-dependent cell spreading; negative regulation of focal adhesion assembly; negative regulation of epithelial cell migration; actin cytoskeleton organization; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	23603
	23790
	ENSG00000110880
	ENSMUSG00000004530
	Q9ULV4
	Q9WUM4
	NM_001105237; NM_001276471; NM_014325
	NM_011779
	NP_001098707; NP_001263400; NP_055140
	NP_035909
	Wikidata
View/Edit Human	View/Edit Mouse

Coronin-1C is a protein that in humans is encoded by the CORO1C gene.^[5]^[6]^[7]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000110880 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004530 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Okumura M, Kung C, Wong S, Rodgers M, Thomas ML (Oct 1998). "Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein". DNA Cell Biol. 17 (9): 779–87. doi:10.1089/dna.1998.17.779. PMID 9778037.
^ de Hostos EL (Oct 1999). "The coronin family of actin-associated proteins". Trends Cell Biol. 9 (9): 345–50. doi:10.1016/S0962-8924(99)01620-7. PMID 10461187.
^ ^a ^b "Entrez Gene: CORO1C coronin, actin binding protein, 1C".

External links

Human CORO1C genome location and CORO1C gene details page in the UCSC Genome Browser.

Rosentreter A, Hofmann A, Xavier CP, et al. (2007). "Coronin 3 involvement in F-actin-dependent processes at the cell cortex". Exp. Cell Res. 313 (5): 878–95. doi:10.1016/j.yexcr.2006.12.015. hdl:10072/14982. PMID 17274980.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Spoerl Z, Stumpf M, Noegel AA, Hasse A (2003). "Oligomerization, F-actin interaction, and membrane association of the ubiquitous mammalian coronin 3 are mediated by its carboxyl terminus". J. Biol. Chem. 277 (50): 48858–67. doi:10.1074/jbc.M205136200. PMID 12377779.
Iizaka M, Han HJ, Akashi H, et al. (2000). "Isolation and chromosomal assignment of a novel human gene, CORO1C, homologous to coronin-like actin-binding proteins". Cytogenet. Cell Genet. 88 (3–4): 221–4. doi:10.1159/000015555. PMID 10828594. S2CID 46548464.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Wick M, Bürger C, Brüsselbach S, et al. (1994). "Identification of serum-inducible genes: different patterns of gene regulation during G0-->S and G1-->S progression". J. Cell Sci. 107 (1): 227–39. doi:10.1242/jcs.107.1.227. PMID 8175911.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

This article on a gene on human chromosome 12 is a stub. You can help Wik.ipedia.Pro by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000110880 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004530 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9778037-5] Okumura M, Kung C, Wong S, Rodgers M, Thomas ML (Oct 1998). "Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein". DNA Cell Biol. 17 (9): 779–87. doi:10.1089/dna.1998.17.779. PMID 9778037.

[pmid10461187-6] Hostos EL (Oct 1999). "The coronin family of actin-associated proteins". Trends Cell Biol. 9 (9): 345–50. doi:10.1016/S0962-8924(99)01620-7. PMID 10461187.

[entrez-7] "Entrez Gene: CORO1C coronin, actin binding protein, 1C".

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CORO1C

References

External links

Further reading

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