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Lateral pontine syndrome

Lateral pontine syndrome
Pons
SpecialtyNeurology 

Lateral pontine syndrome, also known as Marie-Foix syndrome or Marie-Foix-Alajouanine syndrome[1] is one of the brainstem stroke syndromes of the lateral aspect of the pons. A lateral pontine syndrome is a lesion which is similar to the lateral medullary syndrome, but because it occurs in the pons, it also involves the cranial nerve nuclei of the pons.[2]

History

Lateral pontine syndrome was first described in France by French neurologists Pierre Marie (1853-1940), Charles Foix (1882-1927), and Théophile Alajouanine (1890-1980) in 1922. They were the first to identify and describe the symptoms and causes of this syndrome.

In their original description, Pierre Marie, Charles Foix, and Théophile Alajouanine reported findings from autopsies that showed spinal cord necrosis and multiple tortuous and thickened blood vessels on the surface of the spinal cord. This condition was later called necrotizing myelopathy.[3]

They emphasized that in their two cases, no thrombosis was present. They considered the vascular component of the entity they reported to be a wall thickening, without luminal narrowing or obliteration of the cord vessels (arteries as well as veins). They addressed, and ruled out, the possibility of vascular malformations.[4]

These findings significantly contributed to the understanding of this syndrome

Symptoms

Damage to the following areas produces symptoms (from medial to lateral):

Structure affected Effect
Lateral spinothalamic tract Contralateral loss of pain and temperature from the trunk and extremities.
Facial nucleus & facial Nerve (CN.VII) (1) Ipsilateral paralysis of the upper and lower face (lower motor neuron lesion). (2) Ipsilateral loss of lacrimation and reduced salivation. (3) Ipsilateral loss of taste from the anterior two-thirds of the tongue. (4) Loss of corneal reflex (efferent limb).
Principal sensory trigeminal nucleus and tract Ipsilateral loss of all sensory modalities to the face (facial hemianesthesia)
Vestibular Nuclei and intraaxial nerve fibers Nystagmus, nausea, vomiting, and vertigo
Cochlear nuclei and intraaxial nerve fibers Hearing loss - ipsilateral central deafness
Middle & inferior cerebellar peduncle Ipsilateral limb and gait ataxia
Descending sympathetic tract Ipsilateral Horner's syndrome (ptosis, miosis, & anhydrosis)

Causes

The syndrome occurs due to occlusion of perforating branches of the basilar and anterior inferior cerebellar (AICA) arteries.[5][6][7] It can also be caused by an interruption to the blood supply of the anterior inferior cerebellar artery or circumferential arteries.[8]

Treatment

The treatment for lateral pontine syndrome varies greatly, so there are different medications for different symptoms.[9] Sometimes blood thinning agents are prescribed to remove blood flow hindrance.[10] Other than these medications, physical therapy is also necessary[11]

References.

  1. ^ Abdrabou, Ahmed (22 November 2014). "Lateral pontine syndrome | Radiology Reference Article | Radiopaedia.org". Radiopaedia. Retrieved 2024-05-12.
  2. ^ "Lateral pontine syndrome [Neurosurgerypaedia]". neurosurgerypaedia.org. Retrieved 2024-05-12.
  3. ^ Pino-Camposeco, Jorge del; Villanueva-Castro, Eliezer; Ponce-Gómez, Juan Antonio; Ramírez-Aragón, Sergio; Hernández-Hernández, Alan; Arriada-Mendicoa, Juan Nicasio; Pino-Camposeco, Jorge Del; Villanueva-Castro, Eliezer; Ponce-Gómez, Juan Antonio; Ramírez-Aragón, Sergio; Hernández-Hernández, Alan; Arriada-Mendicoa, Juan Nicasio (2023-03-26). "Foix-Alajouanine Syndrome: A Case Report". Cureus. 15 (3): e36696. doi:10.7759/cureus.36696. ISSN 2168-8184. PMC 10128097. PMID 37113340.
  4. ^ https://www.ajnr.org/content/ajnr/11/6/1286.1.full.pdf [bare URL PDF]
  5. ^ Abdrabou, Ahmed (22 November 2014). "Lateral pontine syndrome | Radiology Reference Article | Radiopaedia.org". Radiopaedia. Retrieved 2024-05-12.
  6. ^ "Lateral pontine syndrome [Neurosurgerypaedia]". neurosurgerypaedia.org. Retrieved 2024-05-12.
  7. ^ "Lateral Pontine Syndrome Definition, Symptoms, Causes, Treatment". Health Care Tips and Natural Remedies. Retrieved 2024-05-12.
  8. ^ Campbell, William W. (2012). DeJong's The Neurologic Examination. Lippincott, Williams & Wilkins. p. 338. ISBN 9781469817521.
  9. ^ "Lateral Pontine Syndrome Definition, Symptoms, Causes, Treatment". Health Care Tips and Natural Remedies. Retrieved 2024-05-12.
  10. ^ "Lateral Pontine Syndrome Definition, Symptoms, Causes, Treatment". Health Care Tips and Natural Remedies. Retrieved 2024-05-12.
  11. ^ "Lateral Pontine Syndrome Definition, Symptoms, Causes, Treatment". Health Care Tips and Natural Remedies. Retrieved 2024-05-12.


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