U12 minor spliceosomal RNA

U12 minor spliceosomal RNA
U12 minor spliceosomal RNA
	Predicted secondary structure and sequence conservation of U12
Identifiers
Symbol	U12
Rfam	RF00007
Other data
RNA type	Gene; snRNA; splicing
Domain(s)	Eukaryota
GO	GO:0000371 GO:0045131 GO:0005693
SO	SO:0000399
PDB structures	PDBe

U12 minor spliceosomal RNA is formed from U12 small nuclear (snRNA), together with U4atac/U6atac, U5, and U11 snRNAs and associated proteins, forms a spliceosome that cleaves a divergent class of low-abundance pre-mRNA introns. Although the U12 sequence is very divergent from that of U2, the two are functionally analogous.^[1]

Structure

The predicted secondary structure of U12 RNA is published,.^[2] However, the alternative single hairpin in the 3' end shown here seems to better match the alignment of divergent Drosophila melanogaster and Arabidopsis thaliana sequences.^[3] The sequences U12 introns that are spliced out are collected in a biological database called the U12 intron database.