Vasoactive intestinal peptide receptor
vasoactive intestinal peptide receptor 1 | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | VIPR1 | ||||||
Alt. symbols | RDC1, HVR1, VAPC1 | ||||||
NCBI gene | 7433 | ||||||
HGNC | 12694 | ||||||
OMIM | 192321 | ||||||
RefSeq | NM_004624 | ||||||
UniProt | P32241 | ||||||
Other data | |||||||
Locus | Chr. 3 p22 | ||||||
|
vasoactive intestinal peptide receptor 2 | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | VIPR2 | ||||||
Alt. symbols | VPAC2 | ||||||
NCBI gene | 7434 | ||||||
HGNC | 12695 | ||||||
OMIM | 601970 | ||||||
RefSeq | NM_003382 | ||||||
UniProt | P41587 | ||||||
Other data | |||||||
Locus | Chr. 7 q36.3 | ||||||
|
adenylate cyclase activating polypeptide 1 (pituitary) receptor type I | |||||||
---|---|---|---|---|---|---|---|
Identifiers | |||||||
Symbol | ADCYAP1R1 | ||||||
Alt. symbols | PACAPR | ||||||
NCBI gene | 117 | ||||||
HGNC | 242 | ||||||
OMIM | 102981 | ||||||
RefSeq | NM_001118 | ||||||
UniProt | P41586 | ||||||
Other data | |||||||
Locus | Chr. 7 p14 | ||||||
|
There are two known receptors for the vasoactive intestinal peptide (VIP) termed VPAC1 and VPAC2.[1][2] These receptors bind both VIP and pituitary adenylate cyclase-activating polypeptide (PACAP) to some degree. Both receptors are members of the 7 transmembrane G protein-coupled receptor family.
VPAC1 is distributed widely in the CNS, liver, lung, intestine and T-lymphocytes.
VPAC2 is found in the CNS, pancreas, skeletal muscle, heart, kidney, adipose tissue, testis, and stomach.
Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP) receptors are activated by the endogenous peptides VIP, PACAP-38, PACAP-27, peptide histidine isoleucineamide (PHI), peptide histidine methionineamide (PHM) and peptide histidine valine (PHV). “PACAP type II receptors” (VPAC1 and VPAC2 receptors) display comparable affinity for PACAP and VIP, whereas PACAP-27 and PACAP-38 are >100 fold more potent than VIP as agonists of most isoforms of the PAC1 receptor.[3]
References
- ^ Laburthe M, Couvineau A, Marie JC (2002). "VPAC receptors for VIP and PACAP". Recept. Channels. 8 (3–4): 137–53. doi:10.3109/10606820213680. PMID 12529932.
- ^ Laburthe M, Couvineau A (2002). "Molecular pharmacology and structure of VPAC Receptors for VIP and PACAP". Regul. Pept. 108 (2–3): 165–73. doi:10.1016/S0167-0115(02)00099-X. PMID 12220741. S2CID 21588275.
- ^ "VIP and PACAP receptors". IUPHAR Guide to Pharmacology. The British Pharmacological Society (BPS) and the International Union of Basic and Clinical Pharmacology (IUPHAR).
External links
- "VIP and PACAP Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2007-10-25.
- Receptors,+Vasoactive+Intestinal+Peptide at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
See what we do next...
OR
By submitting your email or phone number, you're giving mschf permission to send you email and/or recurring marketing texts. Data rates may apply. Text stop to cancel, help for help.
Success: You're subscribed now !