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List of cigarette smoke carcinogens

Typical tobacco packaging warning message about the health effect of smoking tobacco
The front of a 20 pack of Marlboro Red cigarettes sold in New Zealand.
Brazil's third batch of graphic images (since replaced), mandatory on all cigarette packs.
Philippines. Graphic tobacco packaging warning messages from 2016 to 2018.

Commercial tobacco smoke is a mixture of more than 5,000 chemicals.[1] A 2011 report in the International Journal of Environmental Research and Public Health (IJERPH) lists 65 carcinogens or possible carcinogens: "Our list of hazardous smoke components includes all nine components reported in mainstream cigarette smoke that are known human carcinogens (IARC Group I carcinogens), as well as all nine components that are probably carcinogenic to humans (IARC Group 2A carcinogens). In addition, it contains 34 of the 48 components that are possibly carcinogenic to humans (IARC Group 2B carcinogens)."[1]

IJERPH table

  • "1Cancer inhalation risk values provide an excess lifetime exposure risk, in this case the human lung cancer risk at a 1 in 100,000 (E-5) level."
Carcinogens or possible carcinogens. IJERPH.[1] Cancer risk value in mg m-3
Smoke component Cancer risk value1 Institute
1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) 1.0E-04 U.S. EPA
1,1-Dimethylhydrazine 2.0E-06 ORNL
1,3-Butadiene 3E-04 U.S. EPA
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TEQ) 2.6E-04 Cal EPA
2-Amino-3-methyl-9H-pyrido[2,3-b]indole (MeAaC) 2.9E-05 Cal EPA
2-Amino-3-methylimidazo[4,5-b]quinoline (IQ) 2.5E-05 Cal EPA
2-Amino-6-methyl[1,2-a:3',2"-d]imidazole (GLu-P-1) 7.1E-06 Cal EPA
2-Aminodipyrido[1,2-a:3',2"-d]imidazole (GLu-P-2) 2.5E-05 Cal EPA
2-Aminonaphthalene 2.0E-05 Cal EPA
2-Nitropropane Cal EPA
2-Toluidine 2.0E-04 Cal EPA
3-Amino-1,4-dimethyl-5H-pyrido [4,3-b]indole (Trp-P-1) 1.4E-06 Cal EPA
3-Amino-1-methyl-5H-pyrido[4,3-b]-indole (Trp-P-2) 1.1E-05 Cal EPA
4-Aminobiphenyl 1.7E-06 Cal EPA
5-Methylchrysene 9.1E-06 Cal EPA
7H-Dibenzo(c,g)carbazole 9.1E-06 Cal EPA
2-Amino-9H-pyrido[2,3-b]indole (AaC) 8.8E-05 Cal EPA
Acetaldehyde 4.5E-03 U.S. EPA
Acetamide 5.0E-04 Cal EPA
Acrylamide 8E-3
Acrylonitrile 1.5E-04 U.S. EPA
Aniline B2—probable human carcinogen U.S. EPA
Arsenic 2.3E-06 U.S. EPA
Benz[a]anthracene 9.1E-05 Cal EPA
Benzene 1.3E-03 U.S. EPA
Benzo[a]pyrene 9.1E-06 Cal EPA
Benzo[j]fluoranthene 9.1E-05 Cal EPA
Beryllium 4.2E-06
Cadmium 5.6E-06 U.S. EPA
Carbazole 1.8E-03 NATA
Chloroform, 4.3E-04 U.S. EPA
Chromium VI 8.3E-07 U.S. EPA
Chrysene 9.1E-04 Cal EPA
Di(2-ethylhexyl) phthalate 4.2E-03 Cal EPA
Dibenzo[a,i]pyrene 9.1E-07 Cal EPA
Dibenzo[a,h]acridine 9.1E-05 Cal EPA
Dibenzo[a,h]anthracene 8.3E-06 Cal EPA
Dibenzo[a,j]acridine 9.1E-05 Cal EPA
Dibenzo[a,h]pyrene 9.1E-07 Cal EPA
Dibenzo[a,l)pyrene 9.1E-07 Cal EPA
Dibenzo[a,e]pyrene 9.1E-06 Cal EPA
Dibenzo[c,g]carbazole 9.1E-06 Cal EPA
Ethyl carbamate 3.5E-05 Cal EPA
Ethylene oxide 1.1E-04 Cal EPA
Ethylenethiourea 7.7E-04 Cal EPA
Formaldehyde 7.7E-04 U.S. EPA
Hydrazine 2.0E-06 U.S. EPA
Indeno(1,2,3-c,d)pyrene 9.1E-05 Cal EPA
Lead 8.3E-04 Cal EPA
N-nitrosodi-n-butylamine (NBUA) 6.3E-06 U.S. EPA
N-nitrosodimethylamine (NDMA) 7.1E-07 U.S. EPA
N-nitrosodiethanolamine 1.3E-05 Cal EPA
N-nitrosodiethylamine 2.3E-07 U.S. EPA
N-nitrosoethylmethylamine 1.6E-06 Cal EPA
N-Nitrosonornicotine (NNN) 2.5E-05 Cal EPA
N-Nitroso-N-propylamine 5.0E-06 Cal EPA
N-nitrosopiperidine 3.7E-06 Cal EPA
N-nitrosopyrrolidine 1.6E-05 U.S. EPA
o-Cresol C- possible human carcinogen U.S. EPA
p-Benzoquinone C- possible human carcinogen U.S. EPA
p-Cresol C- possible human carcinogen U.S. EPA
Polonium-210 925.9 ORNL3
Propylene oxide 2.7E-03 U.S. EPA
Trichloroethylene 82 HC
Vinyl chloride 1.1E-03 U.S. EPA

See also

References

  1. ^ a b c Talhout, Reinskje; Schulz, Thomas; Florek, Ewa; van Benthem, Jan; Wester, Piet; Opperhuizen, Antoon (February 2011). "Hazardous Compounds in Tobacco Smoke". International Journal of Environmental Research and Public Health. 8 (2): 613–628. doi:10.3390/ijerph8020613. ISSN 1661-7827. PMC 3084482. PMID 21556207. See Table 1.
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