Y+L amino acid transporter 2

SLC7A6
Identifiers
Aliases	SLC7A6, LAT-2, LAT3, y+LAT-2, solute carrier family 7 member 6
External IDs	OMIM: 605641; MGI: 2142598; HomoloGene: 62496; GeneCards: SLC7A6; OMA:SLC7A6 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	68,301,823 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	106,925,338 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; gastrocnemius muscle; ; gastric mucosa; ; subcutaneous adipose tissue; ; tibialis anterior muscle; ; left ventricle; ; tibial nerve; ; abdominal fat; ; left lobe of thyroid gland; ; right auricle;
	Top expressed in
	spermatocyte; ; primitive streak; ; embryo; ; neural tube; ; external carotid artery; ; abdominal wall; ; epiblast; ; ventricular zone; ; internal carotid artery; ; otic vesicle;
	More reference expression data
	n/a
Gene ontology
Molecular function	L-amino acid transmembrane transporter activity; antiporter activity; amino acid transmembrane transporter activity; transmembrane transporter activity;
Cellular component	integral component of membrane; basolateral plasma membrane; integral component of plasma membrane; membrane; plasma membrane; intracellular membrane-bounded organelle;
Biological process	cellular amino acid metabolic process; amino acid transmembrane transport; amino acid transport; leukocyte migration; L-alpha-amino acid transmembrane transport; transmembrane transport; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	9057
	330836
	ENSG00000103064
	ENSMUSG00000031904
	Q92536
	Q8BGK6
	NM_001076785; NM_003983
	NM_178798; NM_001357381; NM_001357382
	NP_001070253; NP_003974; NP_001070253.1; NP_003974.3
	NP_848913; NP_001344310; NP_001344311
	Wikidata
View/Edit Human	View/Edit Mouse

Y+L amino acid transporter 2, also known as cationic amino acid transporter, y+ system, is a protein that in humans is encoded by the SLC7A6 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000103064 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031904 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: solute carrier family 7 (cationic amino acid transporter".
^ Pfeiffer R, Rossier G, Spindler B, Meier C, Kühn L, Verrey F (January 1999). "Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family". The EMBO Journal. 18 (1): 49–57. doi:10.1093/emboj/18.1.49. PMC 1171101. PMID 9878049.

Sekine Y, Nishibori Y, Akimoto Y, Kudo A, Ito N, Fukuhara D, Kurayama R, Higashihara E, Babu E, Kanai Y, Asanuma K, Nagata M, Majumdar A, Tryggvason K, Yan K (July 2009). "Amino acid transporter LAT3 is required for podocyte development and function". Journal of the American Society of Nephrology. 20 (7): 1586–96. doi:10.1681/ASN.2008070809. PMC 2709689. PMID 19443642.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (September 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Torrents D, Estévez R, Pineda M, Fernández E, Lloberas J, Shi YB, Zorzano A, Palacín M (December 1998). "Identification and characterization of a membrane protein (y+L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y+L. A candidate gene for lysinuric protein intolerance". The Journal of Biological Chemistry. 273 (49): 32437–45. doi:10.1074/jbc.273.49.32437. hdl:2445/176951. PMID 9829974.
Bröer A, Wagner CA, Lang F, Bröer S (August 2000). "The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine". The Biochemical Journal. 349 Pt 3 (Pt 3): 787–95. doi:10.1042/bj3490787. PMC 1221206. PMID 10903140.
Xu D, Hemler ME (August 2005). "Metabolic activation-related CD147-CD98 complex". Molecular & Cellular Proteomics. 4 (8): 1061–71. doi:10.1074/mcp.M400207-MCP200. PMC 1351277. PMID 15901826.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000103064 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031904 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: solute carrier family 7 (cationic amino acid transporter".

[pmid9878049-6] Pfeiffer R, Rossier G, Spindler B, Meier C, Kühn L, Verrey F (January 1999). "Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family". The EMBO Journal. 18 (1): 49–57. doi:10.1093/emboj/18.1.49. PMC 1171101. PMID 9878049.

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Y+L amino acid transporter 2

See also

References

Further reading

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